Deciphering immune mechanisms in chronic inflammatory demyelinating polyneuropathies
نویسندگان
چکیده
منابع مشابه
Current treatments of chronic immune-mediated demyelinating polyneuropathies.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN), and anti-myelin-associated glycoprotein (anti-MAG) neuropathy are three demyelinating acquired neuropathies, with distinct responses to immunotherapy. In placebo-controlled, double-blind, randomized trials, intravenous immunoglobulin (IVIg) has been effective for CIDP and MMN, and plasmapheresis...
متن کاملAcquired Inflammatory Demyelinating Polyneuropathies: Clinical and Electrodiagnostic
The acquired demyelinating polyneuropathies include acute (AIDP, Guillain-Barre syndrome, GBS) and chronic (CIDP, dysproteinemic) forms which differ primarily in their temporal profile. They are inflammatory-demyelinating diseases of the peripheral nervous System and likely have an immunologic pathogenesis. Although these neuropathies usually have a characteristic presentation, the electromyogr...
متن کاملChronic inflammatory demyelinating polyneuropathy.
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a rare neurological disease. Definitive therapy is not yet established. We report our use of intravenous Immunoglobulin (iv IgG) in two cases of CIDP and review the therapeutic options available. Intravenous IgG is a ubiquitous practical treatment particularly in patients who do not respond to steroids and where a rapid response is req...
متن کاملChronic Inflammatory Demyelinating Polyneuropathy
Touch MEdical MEdia 47 Diabetes mellitus (DM) is a leading cause of peripheral neuropathy.1–3 A distal symmetric sensorimotor polyneuropathy (DSP), is the most common manifestation,4 and is considered to be mainly due to axonal degeneration and progressive loss of nerve fibers.5–7 However, focal and multifocal peripheral nerve lesions, comprising cranial, thoracoabdominal, and limb nerve lesion...
متن کاملChronic inflammatory demyelinating polyneuropathy.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated disease of the peripheral nervous system with a prevalence of 1-2/100,000. Clinical and experimental findings suggest a role of immune pathomechanisms;however, the target antigens are still unknown. Beside classic CIDP with symmetrical proximal and distal paresis, subgroups of CIDP with pure motor or sensory...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2020
ISSN: 2379-3708
DOI: 10.1172/jci.insight.132411